线粒体靶向分子抗肿瘤应用的研究进展

齐雪静,郑楠楠,高亚男,吴琳华,唐景玲

中国药学杂志 ›› 2015, Vol. 50 ›› Issue (9) : 741-744.

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中国药学杂志
PDF(671 KB)
中国药学杂志 ›› 2015, Vol. 50 ›› Issue (9) : 741-744. DOI: 10.11669/cpj.2015.09.001
·综 述·

线粒体靶向分子抗肿瘤应用的研究进展

  • 齐雪静1,郑楠楠1,高亚男1,吴琳华2,唐景玲1*
作者信息 +

Advances in Mitochondrial Targeting Molecules in Anticancer Applications

  • QI Xue-jing1, ZHENG Nan-nan1,GAO Ya-nan1 , WU Lin-hua2, TANG Jing-ling1*
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文章历史 +

摘要

近年来随着对线粒体的深入研究,人们认识到线粒体对于肿瘤细胞凋亡有着至关重要的作用。这一发现促进了人们对线粒体靶向制剂的研究。线粒体靶向分子可以使药物特异性的作用于线粒体,进而诱导细胞凋亡,从而达到抗肿瘤的目的,在提高疗效的同时又降低了药物的毒副作用。因此线粒体靶向分子在抗肿瘤药物中有广阔的应用前景。笔者综述了近年来线粒体靶向分子在肿瘤治疗中的研究进展,为从线粒体途径治疗肿瘤提供参考。

Abstract

In recent years, with the in-depth research on mitochondria, people realize that mitochondria have a vital role for apoptosis of cancer cells. This finding promotes the development of mitochondrial targeting agents. Anticancer drugs modified with mitochondrial targeting molecules specifically acts on mitochondria and induce apoptosis of tumor cells to achieve targeting anti-tumor effect, so that the efficacy is improved while systemic toxicity of anticancer drugs is reduced. Mitochondrial targeting molecules have broad potential applications in anticancer drugs. This paper reviews the latest research progress of mitochondrial targeting molecules for cancer therapy, providing a reference for the treatment of cancer from the mitochondrial pathway

关键词

线粒体靶向分子 / 细胞凋亡 / 抗肿瘤

Key words

mitochondrial targeting molecule / cell apoptosis / anticancer

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齐雪静,郑楠楠,高亚男,吴琳华,唐景玲. 线粒体靶向分子抗肿瘤应用的研究进展[J]. 中国药学杂志, 2015, 50(9): 741-744 https://doi.org/10.11669/cpj.2015.09.001
QI Xue-jing, ZHENG Nan-nan,GAO Ya-nan , WU Lin-hua, TANG Jing-ling. Advances in Mitochondrial Targeting Molecules in Anticancer Applications[J]. Chinese Pharmaceutical Journal, 2015, 50(9): 741-744 https://doi.org/10.11669/cpj.2015.09.001
中图分类号： R944   

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基金

国家自然科学基金资助项目(81302705);黑龙江省自然科学基金资助项目(LC201432)
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